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粘蛋白5B(MUC5B)單克隆抗體

Monoclonal Antibody to Mucin 5 Subtype B (MUC5B)

MUC5-B; MUC9; MG1; Oligomeric Mucus/Gel-Forming; Mucin 5,Subtype B,Tracheobronchial; Cervical mucin; High molecular weight salivary mucin MG1; Sublingual gland mucin

  • 粘蛋白5B(MUC5B)單克隆抗體產品包裝(模擬)
  • 粘蛋白5B(MUC5B)單克隆抗體產品包裝(模擬)
  • 粘蛋白5B(MUC5B)單克隆抗體DAB staining on IHC-P; Sample: Human Small intestine Tissue; Primary Ab: 30μg/ml Mouse Anti-Human MUC5B Antibody Second Ab: 2μg/mL?HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: SAA544Mu19)
  • Certificate通過ISO 9001、ISO 13485質量體系認證

特異性

該抗體是針對MUC5B的小鼠單克隆抗體。在免疫組織化學染色和免疫印跡實驗中能識別MUC5B。

用法

Immunohistochemistry: 5-30μg/mL;
Optimal working dilutions must be determined by end user.

儲存

經常使用則4°C保存。-20°C保存不超過兩年。避免反復凍融。

穩(wěn)定性

熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產生。保質期內，在適當的條件下存儲，損失率低于5%。

贈品

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編號適用物種：Homo sapiens (Human，人)應用(僅供研究使用，不用于臨床診斷！)
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參考文獻

雜志參考文獻
The Journal of Biological ChemistryThe Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase/Ribosomal S6 Protein Kinase 1 Cascade Phosphorylates cAMP Response Element-binding Protein to Induce MUC5B Gene Expression via D-Prostanoid Receptor Signaling[Jcb: 34199]
The Journal of Biological ChemistryThe ERK MAPK/RSK1 cascade phosphorylates CREB to induce MUC5B gene expression via DP1 receptor signaling[Jcb: 247684]
Respiratory ResearhPyocyanin-induced mucin production is associated with redox modification of FOXA2[PubMed: PMC3765780]
RespirologySecreted mucins and airway bacterial colonization in non-CF bronchiectasis[PubMed: 26172851]
American Thoracic Society International Conference AbstractsMucin Secretion In Asthmatics With Osmotic Airway Hyperresponsiveness[doi:10.1164]
Ann Am Thorac SocAirway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization[doi:10.1513]
Секреторно-экссудативная реакция слизистой носа на воздействие холодного воздуха у больных бронхиальной астмой[10.20538/1682-0363-2017-2-146-158]
AllergyTh2 cytokines orchestrate the secretion of MUC 5 AC and MUC 5B in IL‐5 positive chronic rhinosinusitis with nasal polyps[Pubmed:29802623]
European?Journal of Pharmacology?Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling[Pubmed:29382534]
Japan Society of Immunology & Allergology in Otolaryngologyインフルエンザ菌Phosphorylcholine の表出と中耳ムチンMUC5AC 及びMUC5B 産生への影響[10.5648:jjiao.36.7]
Journal of Investigative?MedicineThe characteristics and clinical significance of mucin levels in bronchoalveolar lavage fluid of patients with interstitial lung disease[Pubmed: 30573494]
Mucosal ImmunologyASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism[Pubmed: 31278375]