神經(jīng)調(diào)節(jié)素1(NRG1)真核蛋白
Eukaryotic Neuregulin 1 (NRG1)
ARIA; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor
- 編號EPB866Hu61
- 物種Homo sapiens (Human，人)相同的名稱，不同的物種。
- 來源真核表達
- 宿主293F Cell
- 內(nèi)毒素水平<1.0EU/µg(LAL法測定)
- 亞細胞定位細胞膜, 細胞核, 分泌
- 預測分子量26.41kDa
- 實際分子量45kDa(差異分析請參閱說明書)
- 片段與標簽Ser20~Lys246 with N-terminal His Tag
- 緩沖液成份PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
- 性狀凍干粉
- 純度> 90%
- 等電點8.7
- 應用Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，請參見活性蛋白。 - 下載英文說明書 中文說明書
- 規(guī)格10μg50μg200μg1mg5mg
- 價格暫無報價暫無報價暫無報價暫無報價暫無報價
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產(chǎn)品包裝(模擬)
產(chǎn)品包裝(模擬)
SDS-PAGE圖
通過ISO 9001、ISO 13485質(zhì)量體系認證
序列
用法
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
儲存
避免反復凍融。2-8°C不超過一個月，-80°C不超過12個月。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當?shù)臈l件下存儲，損失率低于5%。
增值服務
相關產(chǎn)品
參考文獻
| 雜志 | 參考文獻 |
| Neuroscience Letter | Therapeutic effect of co-transplantation of neuregulin 1-transfected-Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrom[Cyagen: source] |
| PLoS One. | ADAM17 Silencing in Mouse Colon Carcinoma Cells: The Effect on Tumoricidal Cytokines and Angiogenesis[PubMed: PMC3519469] |
| The Journal of Clinical Investigation | Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegeneration[PubMed: PMC3428100] |
| Physiol Behav | Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stress[PubMed: 26626816] |
| J Toxicol Sci.? | Effects of prolonged antipsychotic administration on neureCavia (Guinea pig )lin-1/ErbB signaling in rat prefrontal cortex and myocardium: implications for the therapeutic action and cardiac adverse effect.[Pubmed:26961615] |
| journal of cellular and molecular medicine | Qiliqiangxin protects against anoxic injury in cardiac microvascular endothelial cells via NRG-1/ErbB-PI3K/Akt/mTOR pathway.[pubmed:28271613] |
| Transl Psychiatry. | Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.[pubmed:28267150] |
| Human?Molecular?Genetics | A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas[Pubmed: 30335132] |
| Aging (Albany NY) | Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut microbiota and neuregulin[Pubmed: 32920546] |