酸性神經鞘磷脂酶(ASM)真核蛋白
Eukaryotic Acid Sphingomyelinase (ASM)
SMPD1; NPD; SMase; aSMase; Sphingomyelin Phosphodiesterase 1,Acid Lysosomal; Simply Sphingomyelinase
- 編號EPB360Hu61
- 物種Homo sapiens (Human，人)相同的名稱，不同的物種。
- 來源真核表達
- 宿主293F cell
- 內毒素水平<1.0EU/µg(LAL法測定)
- 亞細胞定位溶酶體
- 預測分子量64.9kDa
- 實際分子量75kDa(差異分析請參閱說明書)
- 片段與標簽His62~Pro628 with N-terminal His Tag
- 緩沖液成份磷酸鹽緩沖液（pH7.4，含有 0.01% SKL, 1mM DTT, 5% Trehalose和Proclin300.）
- 性狀凍干粉
- 純度> 95%
- 等電點7.2
- 應用Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，請參見活性蛋白。 - 下載英文說明書 中文說明書
- 規(guī)格10μg50μg200μg1mg5mg
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產品包裝(模擬)
產品包裝(模擬)
Figure. SDS-PAGE
通過ISO 9001、ISO 13485質量體系認證
序列
用法
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
儲存
避免反復凍融。2-8°C不超過一個月，-80°C不超過12個月。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產生。保質期內，在適當?shù)臈l件下存儲，損失率低于5%。
增值服務
相關產品
| 編號 | 適用物種：Homo sapiens (Human，人) | 應用(僅供研究使用，不用于臨床診斷！) |
| EPB360Hu61 | 酸性神經鞘磷脂酶(ASM)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB360Hu01 | 酸性神經鞘磷脂酶(ASM)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB360Hu61 | 酸性神經鞘磷脂酶(ASM)活性蛋白 | Cell?culture;?Activity?Assays. |
| PAB360Hu01 | 酸性神經鞘磷脂酶(ASM)多克隆抗體 | WB; IHC; ICC; IP. |
| MAB360Hu22 | 酸性神經鞘磷脂酶(ASM)單克隆抗體 | WB; IHC; ICC; IP. |
| SEB360Hu | 酸性神經鞘磷脂酶(ASM)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| MEB360Hu | 酸性神經鞘磷脂酶(ASM)檢測試劑盒(酶聯(lián)免疫吸附試驗法,小樣本) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMB360Hu | 酸性神經鞘磷脂酶(ASM)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
參考文獻
| 雜志 | 參考文獻 |
| Blood.? | Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD[Pubmed:25075126] |
| Journal of Clinical Lipidology | Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34+ circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes[10.1016/j.jacl.2017.03.007] |
| Diabetes & metabolism | Fenofibrate decreases plasma ceramide in type 2 diabetes patients: A novel marker of CVD?[pubmed:28499696] |
| INFLAMMATION | Acid Sphingomyelinase and Acid |?-Glucosidase 1 Exert Opposite Effects on Interleukin-1|?-Induced Interleukin 6 Production in Rheumatoid Arthritis Fibroblast-Like Synoviocytes[33665756] |
| Indian J Ophthalmol | Evaluation of sphingolipid metabolism on diabetic retinopathy[34708809] |